PEPFAR: Combination Prevention Solutions to reach Epidemic Control in South Africa

Deadline: 20 February 2025

The United States Department of Health and Human Services is seeking grant proposals to provide targeted combination prevention solutions and approaches to vulnerable, high-risk priority populations, including adolescents and young people, aged between 10-24, in workplaces, schools, and communities.

Aims

The NOFO aims to create demand for and support the use of the following prevention and response interventions through direct service delivery, referrals, and technical assistance:
- Evidence-based biomedical interventions such as:
  - HIV testing services.
  - Antiretroviral therapy.
  - Pre-exposure prophylaxis (PrEP).
  - Post-exposure prophylaxis (PEP).
  - Condom promotion and distribution.
  - Sexually transmitted infection (STI) screening and treatment.
  - Sexual and reproductive health.
  - Mental health and substance abuse screening.
  - Psychosocial support.
  - Minimum package of post-violence care.
- Behavioral interventions such as:
  - School and community-based HIV and violence prevention, including health education for all adolescents and youth as well as community leaders, parents, and caregivers.
  - HIV risk reduction.
- Structural HIV, TB, and violence interventions such as social mobilization.
- Youth empowerment such as:
  - Economic strengthening.
  - Gender norm changes.
  - Gender-based violence (GBV) prevention.
  - Family strengthening programs.

Funding Information

Expected total NOFO funding for Year 1: $25,000,000
Expected number of awards: 2. The number of awards is subject to available funds and program priorities
Duration: They plan to award projects for five 12-month budget periods for a five-year period of performance.

Eligible Activities

Implement and scale-up HIV combination prevention solutions in priority districts for vulnerable, high-risk priority populations (adolescents, young people, male sex partners, and their families) to increase their knowledge, risk perception, and service uptake.
Provide high-quality, confidential community HIV testing and counseling services to adolescents, young people, and male sex partners to refer and link them to comprehensive prevention and treatment services.
Collaborate with key stakeholders to design, strengthen, and implement quality youth-responsive HIV services for adolescents and young people, following the national guidelines to improve access to prevention and treatment services.

Eligibility Criteria

This is a fully competitive NOFO, and eligibility is unrestricted. Any and all types of organizations are eligible and encouraged to apply, including but not limited to those listed below:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Native American tribal governments (federally recognized)
- Public housing authorities and Indian housing authorities
- Native American tribal organizations, other than federally recognized tribal governments
- Nonprofits having a 501(c)(3) status, other than institutions of higher education
- Nonprofits without 501(c)(3) status, other than institutions of higher education
- Private institutions of higher education
- For-profit organizations other than small businesses
- Small businesses
- Foreign or non-U.S. based entities.