Deadline: 10 June 2025
The Breakthrough T1D is accepting applications to improve adult diagnosis of type 1 diabetes (T1D), with special emphasis on the early stages of the disease.
Areas of Interest
- Immune Activation and Autoimmunity
- Islet Pathology and Beta Cell Function
- Autoantibodies and Biomarker Validation
- Accuracy in Misdiagnosis and Diagnostic Tools
- Epidemiology Studies
Scopes
- Out of Scope for this request:
- For any approaches focused on genetic risk in adult-onset T1D, please refer to the RFA titled “Advancing Genetic Risk Assessment for Type 1 Diabetes: Improving Prediction and Clinical Translation” launched in parallel with this RFA.
- Exclusive pediatric T1D studies with no clear link to adult-onset T1D.
- Support for research screening programs that require additional recruitment and monitoring of adults to understand the natural history of T1D in this population.
- Studies focusing on disease progression after clinical diagnosis or examining environmental triggers that influence adult-onset T1D.
- Testing of beta cell regenerative agents or therapies.
- Basic research using animal models (e.g. NOD mice) without human clinical relevance.
Funding Information
- This request for application (RFA) will award grants to non-profit and for-profit entities such as academic institutions and industry partners of up to $900,000.00 each and up to 3 years.
Eligibility Criteria
- Applications may be submitted by domestic and foreign non-for-profit organizations, public and private, such as universities, colleges, hospitals and laboratories, units of state and local governments, and eligible agencies of the federal government. Applicants must hold an M.D., D.M.D., D.V.M., Ph.D., or equivalent and have a faculty position or equivalent at a college, university, medical school, or other research facility.
- For-profit entities, or industry collaborations with academia, are welcomed to submit applications in response to this RFA.
- For clinical studies, applicants must hold an appointment or joint appointment in a subspecialty of clinical medicine and conduct human clinical research.
- There are no citizenship requirements for this program. To assure continued excellence and diversity among applicants and awardees, Breakthrough T1D welcomes applications from all qualified individuals and encourages applications from persons with disabilities, women, and members of minority groups underrepresented in the sciences.
Review Criteria
- Applications will be subjected to confidential external scientific review evaluated on the following:
- Significance
- Relevance
- Approach
- Innovation
- Environment
- Resource sharing plan
For more information, visit Breakthrough T1D.
