Apply for Implementation of Findings from PCORI’s Research Investments (US)

The PFA is an open competition opportunity for principal investigators to propose implementation projects that move evidence toward practical use in improving health care and health outcomes.

The funding announcement intends to support meaningful implementation projects that promote the uptake of peer-reviewed findings from specific high-priority PCORI initiatives in the context of the body of related evidence. As such, this funding opportunity seeks to draw on the expertise, creativity, and capacity of a broad applicant pool—including implementation experts and diverse stakeholder partners embedded in the targeted settings where implementation will occur—to fund implementation projects that will lead to the uptake and integration of PCORI-funded evidence into real-world practice settings.

Focus Areas

• For the Cycle 3 2024 PFA, PCORI has identified the following four areas of eligible evidence:
  • Intensive Lifestyle Treatment for Weight Loss in Primary Care Settings: Through a targeted funding initiative, PCORI committed funding to support pragmatic clinical trials to evaluate obesity treatment options in primary care for underserved populations.
  • Nonsurgical Treatment Options to Improve or Eliminate Symptoms for Women with Urinary Incontinence (UI): Millions of women experience urinary incontinence; however, a majority do not receive treatment. A recent systematic review update on this topic found that several nonsurgical treatments for urinary incontinence can help.
  • Therapies and Medicines to Reduce or Eliminate Symptoms for People with Posttraumatic Stress Disorder (PTSD): Findings from a recent systematic review update, which support the strength of evidence for specific treatment approaches for PTSD, underscore the potential for improving patient-centered outcomes through the implementation of effective treatment.
  • Appropriate Antibiotic Prescribing for Children with Acute Respiratory Tract Infections (ARTIs): Current guidelines generally recommend the use of narrow-spectrum antibiotics such as amoxicillin as first-line treatment for ARTIs in children, subject to local conditions with respect to antibiotic resistance.

Funding Information

• Grant amount: Up to $2.5 million in direct costs.
• Duration: 4 years.

Eligibility Criteria

• Eligible Evidence: Applicants must propose implementation projects that focus on the findings PCORI identifies in this PFA, which are drawn from published, peer-reviewed evidence emerging from selected areas of PCORI investment in comparative clinical effectiveness research.
• Eligible Organizations: Applications may be submitted by nonprofit and for profit organizations. US-based applicants must have a Federal Employer Identification Number as assigned by the Internal Revenue Service. Applicants must demonstrate the capability to comply with the terms of the standard agreement associated with each PFA. Potential applicants are strongly encouraged to review the standard agreement before they apply. Standard agreements are available with each PFA through the PCORI Funding Center.

For more information, visit PCORI.