Submissions open for Mark Foundation Endeavor Awards

These grants are awarded to teams of three or more investigators to generate and integrate data from diverse lines of research and transform those insights into advances for cancer patients that could not be achieved by individual efforts.

Award Terms

• Endeavor Awards are $3,000,000 disbursed over a 3-year term.
  • The requested funding should be divided amongst team members in a manner proportional to the actual cost of the work carried out by each investigator for the project.
  • The budget limit includes both direct and indirect costs, with indirect costs not to exceed 10% of the direct costs.
  • The third year of funding will be contingent on sufficient scientific progress as presented at the 18-month project review.
  • The letter of agreement will include IP terms with a revenue sharing component.

Team Roles

• Principal Investigator (PI) – 1 per team
  • Serves as the single point of contact with MFCR during the application process and the grant period.
  • The LOA will be executed solely with the PI’s institution.
  • Must meet all criteria of a co-PI listed below.
  • Does not need to be the most senior member of the team.
• Co-Principal Investigator (co-PI) – 2 to 8 per team
  • Lab receives at least 10% of the total grant budget.
  • Core member of the team leadership.
  • Designated as key personnel in the LOA.
  • Must have an independent faculty research appointment (tenure-track or equivalent).
• Collaborator – optional
  • Lab receives 0-10% of the budget.
  • Can provide resources, perform experiments, analyses, etc.
  • Serves as a project consultant or advisor rather than a team leader.

Eligibility Criteria

• Institutional Eligibility:
  • Open to non-profit academic/research institutions.
  • Open to institutions worldwide.
  • Teams may comprise investigators from a single institutions or multiple institutions.
  • There is no requirement to include a US-based institution as part of the team.
  • Institutions may submit more than one application.
• Investigator Eligibility:
  • There are no restrictions on citizenship or geography.
  • Applicants must have an independent faculty research appointment (tenure-track or equivalent) at a non-profit academic institution.
  • Investigators may be co-PI or collaborator on more than one proposal but may only serve as Principal Investigator on one proposal.
  • Investigators who are currently a co-PI on an Endeavor team are permitted to apply as co-PI or collaborator on a new application.
• Project Eligibility:
  • Basic, translational, and clinical projects are eligible.
  • The project must seek to address an overarching, urgent scientific question.
  • Sub-projects should be designed to elucidate various aspects of the overarching question, theme, or focus.
  • The output of the individual team members (data, samples, hypotheses, compounds, etc.) must be integrated and/or shared in a way that makes the impact of the project as a whole larger than the sum of its parts.
  • Proposed projects must not be supported by other sources of funding. Finalists will be asked to discuss any potential overlap with other current or pending awards.
• Team Composition:
  • Teams must be composed of one PI, and between 2-8 co-PIs.
  • Inter-institutional collaborations are permitted and encouraged.
  • Teams are encouraged to consider diversity in terms of discipline, seniority, gender, race, ethnicity, and any other parameters that will enhance the team’s ability to approach challenging problems from fresh perspectives.
  • The Mark Foundation for Cancer Research does not discriminate on the basis of race, color, religion, national origin, sex, gender identity, sexual orientation, age, disability, or any other legally protected characteristics.

For more information, visit The Mark Foundation for Cancer Research.