Call for Applications: Broad Pragmatic Studies Funding (US)

Topic & Themes

• The purpose of identifying these Topic Themes is to encourage submissions to these areas, not to limit submissions to only these themes. The BPS PFA welcomes all investigator-initiated research in patient-centered comparative clinical effectiveness that meets the requirements of this PFA. The Topic Themes, clustered into three groups, are as follows:
  • Populations:
    • Improving outcomes for people with intellectual and developmental disabilities (IDD)
    • Promoting health for older adults
    • Promoting healthy children and youth
  • Health Behaviors:
    • Addressing substance use
    • Addressing violence and trauma
  • Health Conditions:
    • Addressing COVID-19
    • Addressing rare diseases
    • Improving cardiovascular health
    • Improving mental and behavioral health
    • Managing pain
    • Preventing maternal morbidity and mortality (MMM)
    • Promoting sleep health

Special Areas of Emphasis

• Social Isolation and Loneliness in Older Adults: PCORI is interested in supporting high quality patient-centered CER testing the impact of interventions to address social isolation and loneliness in older adults.
• Health Communication Strategies for Uptake of COVID-19 Vaccine: PCORI is interested in supporting high-quality, patient-centered CER projects comparing health communication strategies to promote COVID-19 vaccine uptake among U.S. adults and children. Other vaccines may also be incorporated along with COVID-19.
• Promoting Sleep Health in Inpatient Settings: Sleep is fundamental to recovery from acute illness; however, sleep disturbance in inpatient settings is common and contributes to worse health outcomes.

Funding Information

• Category 1: will support research projects with direct costs up to and including $5 million.
• Category 2: will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applicants for funding under Category 2 will be expected to justify the size and scope of the proposed research and why additional funds are necessary to support the scale, scope, and complexity of personnel and material resources needed to address the research question.
• Category 3: will support research projects with direct costs up to $12 million that use PCORnet to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement.

Eligibility Criteria

• In general, applications for the conduct of research and management of funding may be submitted by appropriate academic research, private sector research, or study-conducting entities. This may include, among others, agencies and instrumentalities of the federal government, nonprofit and forprofit research organizations, and colleges and universities.

For more information, visit PCORI.